¹⁸F-FSPG PET/CT Imaging of System x_C^- Transporter Activity in Patients with Primary and Metastatic Brain Tumors.

ABSTRACT: Background The PET tracer (4S)-4-(3-[¹⁸F]fluoropropyl)-l-glutamate (¹⁸F-FSPG) targets the system x_C^- cotransporter, which is overexpressed in various tumors. Purpose To assess the role of ¹⁸F-FSPG PET/CT in intracranial malignancies. Materials and Methods Twenty-six patients (mean age, 54 years ± 12; 17 men; 48 total lesions) with primary brain tumors (n = 17) or brain metastases (n = 9) were enrolled in this prospective, single-center study (ClinicalTrials.gov identifier: NCT02370563) between November 2014 and March 2016. A 30-minute dynamic brain ¹⁸F-FSPG PET/CT scan and a static whole-body (WB) ¹⁸F-FSPG PET/CT scan at 60-75 minutes were acquired. Moreover, all participants underwent MRI, and four

SUBMITTER: Wardak M 

PROVIDER: S-EPMC9131170 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature