Global hemostatic profiling in patients with decompensated cirrhosis and bacterial infections.

ABSTRACT:

Background & aims

Bacterial infections in cirrhosis are associated with increased bleeding risk. To assess the factors responsible for bleeding tendency in patients with bacterial infections, we conducted a prospective study comparing all 3 aspects of hemostasis (platelets, coagulation, and fibrinolysis) in hospitalized patients with decompensated cirrhosis with vs. without bacterial infections.

Methods

Primary hemostasis assessment included whole blood platelet aggregation and von Willebrand factor (VWF). Coagulation assessment included procoagulant factors (fibrinogen, factor II, V, VII, VIII, IX, X, XI, XII, XIII), natural anticoagulants (protein C, protein S, antithrombin) and thrombomodulin-modified thrombin generation test. Fibrinolysis assessment included fibri

SUBMITTER: Zanetto A 

PROVIDER: S-EPMC9131254 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature