Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancer.

ABSTRACT: Background: Gastric cancer remains the third most common cause of cancer-related death worldwide. The development of novel therapeutic strategies for gastric cancer requires a deep understanding of the tumor cells and microenvironment of gastric cancer. Methods: We performed the single-cell RNA sequencing (scRNA-seq) on nine untreated non-metastatic gastric cancer patients. The transcriptomic atlas and ligand-receptor-based intercellular communication networks of the single cells were characterized. Results: Here, we profiled the transcriptomes of 47,304 cells from nine patients with gastric cancer. Tregs cells were significantly enriched in the gastric tumor tissues with increased expression of immune suppression related genes, which suggest a more immunosuppressive m

SUBMITTER: Li Y 

PROVIDER: S-EPMC9131288 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature