Inductive Remodeling of Extracellular Matrix Scaffolds in the Temporomandibular Joint of Pigs.

ABSTRACT: The temporomandibular joint (TMJ) disc is a fibrocartilaginous tissue located between the condyle of the mandible and glenoid fossa and articular eminence of the temporal bone. Damage or derangement of the TMJ disc can require surgical removal (discectomy) to restore function. Removal of the TMJ disc, however, leaves the joint space vulnerable to condylar remodeling and degradation, potentially leading to long-term complications. No consistently effective clinical option exists for repair or replacement of the disc following discectomy. This study investigates the use of an acellular scaffold composed of extracellular matrix (ECM) derived from small intestinal submucosa (SIS) as a regenerative template for the TMJ disc in a porcine model. Acellular SIS ECM scaffolds were implanted followin

SUBMITTER: Brown BN 

PROVIDER: S-EPMC9131358 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature