Synthesis and In Vitro Studies of Photoactivatable Semisquaraine-type Pt(II) Complexes.

ABSTRACT: The synthesis, full characterization, photochemical properties, and cytotoxic activity toward cisplatin-resistant cancer cell lines of new semisquaraine-type Pt(II) complexes are presented. The synthesis of eight semisquaraine-type ligands has been carried out by means of an innovative, straightforward methodology. A thorough structural NMR and X-ray diffraction analysis of the new ligands and complexes has been done. Density functional theory calculations have allowed to assign the trans configuration of the platinum center. Through the structural modification of the ligands, it has been possible to synthesize some complexes, which have turned out to be photoactive at wavelengths that allow their activation in cell cultures and, importantly, two of them show remarkable solubility i

SUBMITTER: Morales K 

PROVIDER: S-EPMC9131461 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature