Selectivity of afferent microstimulation at the DRG using epineural and penetrating electrode arrays.

ABSTRACT:

Objective

We have shown previously that microstimulation of the lumbar dorsal root ganglia (L5-L7 DRG) using penetrating microelectrodes, selectively recruits distal branches of the sciatic and femoral nerves in an acute preparation. However, a variety of challenges limit the clinical translatability of DRG microstimulation via penetrating electrodes. For clinical translation of a DRG somatosensory neural interface, electrodes placed on the epineural surface of the DRG may be a viable path forward. The goal of this study was to evaluate the recruitment properties of epineural electrodes and compare their performance with that of penetrating electrodes. Here, we compare the number of selectively recruited distal nerve branches and the threshold stimulus intensities between penetrati

SUBMITTER: Nanivadekar AC 

PROVIDER: S-EPMC9131467 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature