Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii.

ABSTRACT:

Background

Lysine lactylation (Kla) is a novelposttranslational modification (PTM) identified in histone and nonhistone proteins of several eukaryotic cells that directly activates gene expression and DNA replication. However, very little is known about the scope and cellular distribution of Kla in apicomplexan parasites despite its significance in public and animal health care.

Methods

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular apicomplexan parasite that can infect different nucleated cell types of animals and humans. We used this parasite as a model organism and extracted the total protein of tachyzoites to produce the first global lysine lactylome profile of T. gondii through liquid chromatography-tandem mass spectrometry. We als

SUBMITTER: Zhao W 

PROVIDER: S-EPMC9131557 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature