Parkinson's disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study.

ABSTRACT:

Background

Inflammations play crucial role in the pathogenesis of Parkinson's disease (PD), however, their possible value in the diagnosis or tracking of the progress of PD is still limited, because of discordant results in the literature and a lack of information regarding its reproducibility. Thus, overall longitudinal and cross-sectional studies are needed. This multicentre study was designed to investigate the association between multiple peripheral immune biomarkers and the development and progression of PD.

Methods

This was a longitudinal and multicentre study. First, we measured the levels of five typical cytokines and five focused chemokines in 76 PD patients and 76 healthy controls (HCs) in a discovery cohort. Then, a validation cohort of 80 PD and 80 HC participant

SUBMITTER: Li Y 

PROVIDER: S-EPMC9131564 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature