Identification of an endoplasmic reticulum stress-related signature associated with clinical prognosis and immune therapy in glioma.

ABSTRACT:

Background

Glioma is the most common brain tumor in adults and is characterized by a short survival time and high resistance to chemotherapy. It is imperative to determine the prognosis and therapy-related targets for glioma. Endoplasmic reticulum stress (ERS), as an adaptive protective mechanism, indicates the unfolded protein response (UPR) to determine cell survival and affects chemotherapy sensitivity, which is related to the prognosis of glioma.

Methods

Our research used the TCGA database as the training group and the CGGA database as the testing group. Lasso regression and Cox analysis were performed to construct an ERS signature-based risk score model in glioma. Three methods (time-dependent receiver operating characteristic analysis and multivariate and univariate Co

SUBMITTER: Li L 

PROVIDER: S-EPMC9131635 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature