Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is more prone to distant metastasis and visceral recurrence in comparison to other breast cancer subtypes, and is related to dismal prognosis. Nevertheless, TNBC has an undesirable response to targeted therapies. Therefore, to tackle the huge challenges in the diagnosis and treatment of TNBC, Nectin-4 was selected as a theranostic target because it was recently found to be highly expressed in TNBC. We developed anti-Nectin-4 monoclonal antibody (mAb_Nectin-4)-based theranostic pair, ^99mTc-HYNIC-mAb_Nectin-4 and mAb_Nectin-4-ICG. ^99mTc-HYNIC-mAb_Nectin-4 was applied to conduct immuno-single photon emission computed tomography (SPECT) for TNBC diagnosis and classification, an

SUBMITTER: Shao F 

PROVIDER: S-EPMC9131648 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature