Estimating HLA haplotype frequencies from homozygous individuals - A Technical Report.

ABSTRACT: We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation-maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.

SUBMITTER: Seitz S 

PROVIDER: S-EPMC9131737 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature