Risk of C1q variation in systemic lupus erythematosus: a meta-analysis with Trial Sequential Analysis.

ABSTRACT:

Introduction

Systemic lupus erythematosus (SLE) is an autoimmune disease closely related to the immune system. C1q is an important component of complement system. However, the correlation between C1q gene polymorphism and SLE has not been completely unified.

Aim

The primary aim of this meta-analysis was to examine the association between C1q polymorphisms and the risk of SLE.

Material and methods

All relevant articles were retrieved from PubMed, Web of Science and CNKI until June 2020. Pooled OR and 95% CI with random model were used to evaluate the strength of the association between C1q polymorphisms and SLE. Considering the limited number of studies, Trial Sequential Analysis (TSA) was applied to estimate whether the information was sufficient to make reliable and

SUBMITTER: Wang H 

PROVIDER: S-EPMC9131952 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature