The Growing Medical Need for Tracheal Replacement: Reconstructive Strategies Should Overcome Their Limits.

ABSTRACT: Breathing, being predominantly an automatic action, is often taken for granted. However, respiratory diseases affect millions of people globally, emerging as one of the major causes of disability and death overall. Among the respiratory dysfunctions, tracheal alterations have always represented a primary challenge for clinicians, biologists, and engineers. Indeed, in the case of wide structural alterations involving more than 50% of the tracheal length in adults or 30% in children, the available medical treatments are ineffective or inapplicable. So far, a plethora of reconstructive approaches have been proposed and clinically applied to face this growing, unmet medical need. Unfortunately, none of them has become a well-established and routinely applied clinical procedure to date. This re

SUBMITTER: Adamo D 

PROVIDER: S-EPMC9132048 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature