Subgingival Microbiome in Pregnancy and a Potential Relationship to Early Term Birth.

ABSTRACT:

Background

Periodontal disease in pregnancy is considered a risk factor for adverse birth outcomes. Periodontal disease has a microbial etiology, however, the current state of knowledge about the subgingival microbiome in pregnancy is not well understood.

Objective

To characterize the structure and diversity of the subgingival microbiome in early and late pregnancy and explore relationships between the subgingival microbiome and preterm birth among pregnant Black women.

Methods

This longitudinal descriptive study used 16S rRNA sequencing to profile the subgingival microbiome of 59 Black women and describe microbial ecology using alpha and beta diversity metrics. We also compared microbiome features across early (8-14 weeks) and late (24-30 weeks) gestation overall and

SUBMITTER: Yang I 

PROVIDER: S-EPMC9132049 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature