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Tackling antimicrobial stewardship through synergy and antimicrobial peptides.

ABSTRACT: The unrestricted use of antibiotics has led to rapid development of antibiotic resistance (AR) and renewed calls to address this serious problem. This review summarizes the most common mechanisms of antibiotic action, and in turn antibiotic resistance, as well as pathways to mitigate the harm. Focus is then turned to emerging antibiotic strategies, including antimicrobial peptides (AMPs), with a discussion of their modes of action, biochemical features, and potential challenges for their use as antibiotics. The role of synergy in antimicrobials is also examined, with a focus on the synergy of AMPs and other emerging interactions with synergistic potential.

SUBMITTER: Greve JM

PROVIDER: S-EPMC9132191 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Tackling antimicrobial stewardship through synergy and antimicrobial peptides.

Greve Jenna M JM Cowan James A JA

RSC medicinal chemistry 20220404 5

The unrestricted use of antibiotics has led to rapid development of antibiotic resistance (AR) and renewed calls to address this serious problem. This review summarizes the most common mechanisms of antibiotic action, and in turn antibiotic resistance, as well as pathways to mitigate the harm. Focus is then turned to emerging antibiotic strategies, including antimicrobial peptides (AMPs), with a discussion of their modes of action, biochemical features, and potential challenges for their use as ...[more]

PMID: 35694695

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