Increased miR-155 in Microglial Exosomes Following Heat Stress Accelerates Neuronal Autophagy via Their Transfer Into Neurons.

ABSTRACT:

Background

Heat stroke is the outcome of excessive heat stress, which results in core temperatures exceeding 40°C accompanied by a series of complications. The brain is particularly vulnerable to damage from heat stress. In our previous studies, both activated microglia and increased neuronal autophagy were found in the cortices of mice with heat stroke. However, whether activated microglia can accelerate neuronal autophagy under heat stress conditions is still unknown. In this study, we aimed to investigate the underlying mechanism that caused neuronal autophagy upregulation in heat stroke from the perspective of exosome-mediated intercellular communication.

Methods

In this study, BV2 and N2a cells were used instead of microglia and neurons, respectively. Exosomes were extr

SUBMITTER: Li P 

PROVIDER: S-EPMC9132214 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature