Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β).

ABSTRACT: Organic solute transporter α/β (OSTα/β) is a bidirectional bile acid transporter localized on the basolateral membrane of hepatic, intestinal, and renal epithelial cells. OSTα/β plays a critical role in intestinal bile acid reabsorption and is upregulated in hepatic diseases characterized by elevated bile acids, whereas genetic variants in SLC51A/B have been associated with clinical cholestasis. OSTα/β also transports and is inhibited by commonly used medications. However, there is currently no high-resolution structure of OSTα/β, and structure-function data for OSTα, the proposed substrate-binding subunit, are lacking. The present study addressed this knowledge gap and identified amino acids in OSTα that are important f

SUBMITTER: Murphy WA 

PROVIDER: S-EPMC9132218 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature