Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program.

ABSTRACT:

Background

Genetic studies may help identify causal pathways; therefore, we sought to identify genetic determinants of ideal CVH and their association with CVD outcomes in the multi-population Veteran Administration Million Veteran Program.

Methods

An ideal health score (IHS) was calculated from 3 clinical factors (blood pressure, total cholesterol, and blood glucose levels) and 3 behavioral factors (smoking status, physical activity, and BMI), ascertained at baseline. Multi-population genome-wide association study (GWAS) was performed on IHS and binary ideal health using linear and logistic regression, respectively. Using the genome-wide significant SNPs from the IHS GWAS, we created a weighted IHS polygenic risk score (PRSIHS) which was used (i) to conduct a phenome-wide a

SUBMITTER: Huang RDL 

PROVIDER: S-EPMC9132265 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature