Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies.

ABSTRACT: We undertook a prospective temporal study collecting blood samples from consenting pregnant women, to test the hypothesis that circulating extracellular vesicles (EVs) carrying specific non-coding microRNA signatures can underlie gestational diabetes mellitus (GDM). To test this hypothesis, miRNA cargo of isolated and characterized EVs revealed contributions from the placenta and differential expression at all three trimesters and at delivery between pregnant and non-pregnant states. Many miRNAs originate from the placental-specific chromosome 19 microRNA cluster (19MC) and chromosome 14 microRNA cluster (14MC). Further a positive correlation emerged between third trimester and at delivery EVs containing miRNAs and those expressed by the corresponding post-parturient placentas (R value = 0

SUBMITTER: Thamotharan S 

PROVIDER: S-EPMC9132306 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature