Epidemiological analysis of coronary heart disease and its main risk factors: are their associations multiplicative, additive, or interactive?

ABSTRACT:

Objective

The purpose of this study was to discover how considering multiplicative, additive, and interactive effects modifies results of a prospective cohort study on coronary heart disease (CHD) incidence and its main risk factors.

Material and methods

The Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study provided the study material, 2682 Eastern Finnish middle-aged men, followed since the 1980s. We applied multiplicative and additive survival models together with different statistical metrics and confidence intervals for risk ratios and risk differences to estimate the nature of associations.

Results

The mean (SD) follow-up time among men who were free of CHD at baseline (n = 1958) was 21.4 (10.4) years, and 717 (37%) of them had the disease and 301 (1

SUBMITTER: Voutilainen A 

PROVIDER: S-EPMC9132387 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature