Modelling the coupling of the M-clock and C-clock in lymphatic muscle cells.

ABSTRACT: Chronic dysfunction of the lymphatic vascular system results in fluid accumulation between cells: lymphoedema. The condition is commonly acquired secondary to diseases such as cancer or the associated therapies. The primary driving force for fluid return through the lymphatic vasculature is provided by contractions of the muscularized lymphatic collecting vessels, driven by electrochemical oscillations. However, there is an incomplete understanding of the molecular and bioelectric mechanisms involved in lymphatic muscle cell excitation, hampering the development and use of pharmacological therapies. Modelling in silico has contributed greatly to understanding the contributions of specific ion channels to the cardiac action potential, but modelling of these processes in lymphatic muscle rem

SUBMITTER: Hancock EJ 

PROVIDER: S-EPMC9132416 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature