Virulence adaption to environment promotes the age-dependent nasal colonization of Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is an important human commensal bacteria colonizing the human body, especially the nasal cavity. The nasal carriage can be a source of S. aureus bacteremia. However, the bacterial factors contributing to nasal colonization are not completely understood. By analysing S. aureus strains from the nasal cavity of the children, young adults, and seniors, we found that the low activity of the SaeRS two-component system (TCS) is an important determinant for S. aureus to colonize in seniors. The senior group isolates of S. aureus showed a rather distinct sequence type composition as compared with other age group isolates. The senior group isolates showed not only a lower gene carriage of enterotoxins a, c, and q but also lower hemolytic activ

SUBMITTER: Zhao N 

PROVIDER: S-EPMC9132443 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature