Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.
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ABSTRACT:
SUBMITTER: Tsujikawa K
PROVIDER: S-EPMC9132466 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.
Tsujikawa Koyo K Hamanaka Kohei K Riku Yuichi Y Hattori Yuki Y Hara Norikazu N Iguchi Yohei Y Ishigaki Shinsuke S Hashizume Atsushi A Miyatake Satoko S Mitsuhashi Satomi S Miyazaki Yu Y Kataoka Mayumi M Jiayi Li L Yasui Keizo K Kuru Satoshi S Koike Haruki H Kobayashi Kenta K Sahara Naruhiko N Ozaki Norio N Yoshida Mari M Kakita Akiyoshi A Saito Yuko Y Iwasaki Yasushi Y Miyashita Akinori A Iwatsubo Takeshi T Ikeuchi Takeshi T Miyata Takaki T Sobue Gen G Matsumoto Naomichi N Sahashi Kentaro K Katsuno Masahisa M
Science advances 20220525 21
While amyloid-β lies upstream of tau pathology in Alzheimer's disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, but how the nonmutated tau, which most cases with PSP share, increases its propensity to aggregate in neurons and glial cells has remained elusive. Here, we identified genetic variations and protein abundance of filamin-A in the PSP brains without tau mutations. ...[more]
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