Ontology highlight
ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC9132474 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Dong Yanli Y Li Hang H Ilie Alina A Gao Yiwei Y Boucher Annie A Zhang Xuejun Cai XC Orlowski John J Zhao Yan Y
Science advances 20220525 21
Sodium-proton exchanger 3 (NHE3/SLC9A3) located in the apical membrane of renal and gastrointestinal epithelia mediates salt and fluid absorption and regulates pH homeostasis. As an auxiliary regulatory factor of NHE proteins, calcineurin B homologous protein 1 (CHP1) facilitates NHE3 maturation, plasmalemmal expression, and pH sensitivity. Dysfunctions of NHE3 are associated with renal and digestive system disorders. Here, we report the cryo-electron microscopy structure of the human NHE3-CHP1 ...[more]