Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein.

ABSTRACT:

Context

Coronavirus disease 2019 is a global pandemic. Studies suggest that folic acid has antiviral effects. Molecular docking shown that folic acid can act on SARS-CoV-2 Nucleocapsid Phosphoprotein (SARS-CoV-2 N).

Objective

To identify novel molecular therapeutic targets for SARS-CoV-2.

Materials and methods

Traditional Chinese medicine targets and virus-related genes were identified with network pharmacology and big data analysis. Folic acid was singled out by molecular docking, and its potential target SARS-CoV-2 N was identified. Inhibition of SARS-CoV-2 N of folic acid was verified at the cellular level.

Results

In total, 8355 drug targets were potentially involved in the inhibition of SARS-CoV-2. 113 hub genes were screened by further association analysi

SUBMITTER: Chen YM 

PROVIDER: S-EPMC9132477 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature