Higher-Dose Primaquine to Prevent Relapse of <i>Plasmodium vivax</i> Malaria.

ABSTRACT:

Background

In most of the Americas, the recommended treatment to prevent relapse of Plasmodium vivax malaria is primaquine at a total dose of 3.5 mg per kilogram of body weight, despite evidence of only moderate efficacy.

Methods

In this trial conducted in Brazil, we evaluated three primaquine regimens to prevent relapse of P. vivax malaria in children at least 5 years of age and in adults with microscopy-confirmed P. vivax monoinfection. All the patients received directly observed chloroquine for 3 days (total dose, 25 mg per kilogram). Group 1 received a total primaquine dose of 3.5 mg per kilogram (0.5 mg per kilogram per day) over 7 days with unobserved administration; group 2 received the same regimen as group 1 but with observed administration; and

SUBMITTER: Chamma-Siqueira NN 

PROVIDER: S-EPMC9132489 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature