Effect of local application of platelet-rich fibrin scaffold loaded with simvastatin on peri-implant bone changes.

ABSTRACT:

Aim

The purpose of this study was to compare the effects of autologous platelet-rich fibrin (PRF) alone and PRF loaded with SIM on peri-implant bone changes and implant stability in patients undergoing implant rehabilitation.

Settings and design

This was a nonrandomized controlled split-mouth study.

Materials and methods

The study included 8 males between the ages of 45 and 60 years. Each patient received two implants, one on each side of the arch. One side was treated with PRF alone and the other side with PRF loaded with SIM at the time of osteotomy. A cone-beam computed tomography was used to evaluate bone changes around the insertion of implant sites at 3, 6, and 12 months postoperatively. The secondary outcome included measuring implant stability using Osstell de

SUBMITTER: El Shafei SF 

PROVIDER: S-EPMC9132502 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature