Human gut bacteria produce Τ_Η17-modulating bile acid metabolites.

ABSTRACT: The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (T_H17 cells). We previously reported that the bile acid metabolite 3-oxolithocholic acid (3-oxoLCA) inhibits T_H17 cell differentiation¹. Although it was suggested that gut-residing bacteria produce 3-oxoLCA, the identity of such bacteria was unknown, and it was unclear whether 3-oxoLCA and other immunomodulatory bile acids are associated with inflammatory pathologies in humans. Here we identify human gut bacteria and corresponding enzymes that convert the secondary bile acid lithocholic acid into 3-oxoLCA as well as the abundant gut metabolite isolithocholic acid (isoLCA). Similar to 3-oxo

SUBMITTER: Paik D 

PROVIDER: S-EPMC9132548 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature