Risk and Prognostic Factors for BRAF^V600E Mutations in Papillary Thyroid Carcinoma.

ABSTRACT:

Background

Over the past ten years, the incidence rate of papillary thyroid carcinoma (PTC) worldwide has been increasing rapidly year by year, with the incidence rate increasing 6% annually. PTC has become the malignant tumor with the highest growth rate in the world that fourteen PTC-related mutant genes have been identified. Whether the BRAF^V600E mutation related to more aggressive clinicopathologic features and worse outcome in PTC remains variable and controversial. We aim to investigate the risk factors that may predict the BRAF^V600E mutation potential of these lesions and new prevention strategies in PTC patients.

Methods

A total of 9,908 papillary thyroid carcinoma patients with average 74.6% BRAF^V600E mutations were analyzed (RevMan

SUBMITTER: Wei X 

PROVIDER: S-EPMC9132653 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature