Identification of an Inflammatory Response-Related Gene Signature to Predict Survival and Immune Status in Glioma Patients.

ABSTRACT:

Background

Glioma is the most common primary brain tumor with high mortality and poor outcomes. As a hallmark of cancers, inflammatory responses are crucial for their progression. The present study is aimed at exploring the prognostic value of inflammatory response-related genes (IRRGs) and constructing a prognostic IRRG signature for gliomas.

Materials and methods

We investigated the relationship between IRRGs and gliomas by integrating the transcriptomic data for gliomas from public databases. Differentially expressed IRRGs (DE-IRRGs) were identified in the GSE4290 cohort. Further, univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses were conducted to construct an IRRG signature using The Cancer Genome Atlas (TCGA) cohort. G

SUBMITTER: Yan Z 

PROVIDER: S-EPMC9132661 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature