Time point-independent tumor positivity of ⁶⁸Ga-PSMA-PET/CT pre- and post-biopsy in high-risk prostate cancer.

ABSTRACT:

Objective

Prostate-specific membrane antigen (PSMA)-PET/CT imaging has gained increasing clinical importance for the detection and staging of high-risk primary prostate cancer (PCa). However, it is unclear whether the routine practice of prostate biopsy obscures the image finding of PSMA-PET/CT. This study aimed to compare the tumor positivity rate of PSMA-PET/CT performed pre- (PSMA-PET/CT_pre) and post-biopsy (PSMA-PET/CT_post) in high-risk PCa patients.

Patients and methods

We matched 58 PSMA-PET/CT_post with 58 PSMA-PET/CT_pre studies for primary detection of high-risk PCa according to clinical characteristics. Three subgroups of PSMA-PET/CT_post were defined by the intervals after biopsy (≤ 1 week, 1 ~ 2 weeks, and 2 ~ 5

SUBMITTER: Zou S 

PROVIDER: S-EPMC9132805 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature