Chitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial.

ABSTRACT: Chitin-glucan (CG), an insoluble dietary fiber, has been shown to improve cardiometabolic disorders associated with obesity in mice. Its effects in healthy subjects has recently been studied, revealing its interaction with the gut microbiota. In this double-blind, randomized, cross-over, twice 3-week exploratory study, we investigated the impacts of CG on the cardiometabolic profile and gut microbiota composition and functions in 15 subjects at cardiometabolic risk. They consumed as a supplement 4.5 g of CG daily or maltodextrin as control. Before and after interventions, fasting and postprandial metabolic parameters and exhaled gases (hydrogen [H₂] and methane [CH₄]) were evaluated. Gut microbiota composition (16S rRNA gene sequencing analysis), fecal concentrations

SUBMITTER: Ranaivo H 

PROVIDER: S-EPMC9132890 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature