Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

ABSTRACT: In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via t

SUBMITTER: Horgue LF 

PROVIDER: S-EPMC9132991 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature