In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model.

ABSTRACT: Methods of tissue engineering continue to advance, and multiple clinical trials are underway evaluating tissue engineered vascular grafts (TEVGs). Whereas initial concerns focused on suture retention and burst pressure, there is now a pressing need to design grafts to have optimal performance, including an ability to grow and remodel in response to changing hemodynamic loads. Toward this end, there is similarly a need for computational methods that can describe and predict the evolution of TEVG geometry, composition, and material properties while accounting for changes in hemodynamics. Although the ultimate goal is a fluid-solid-growth (FSG) model incorporating fully 3D growth and remodeling and 3D hemodynamics, lower fidelity models having high computational efficiency promise to play imp

SUBMITTER: Latorre M 

PROVIDER: S-EPMC9133046 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature