Ontology highlight
ABSTRACT:
SUBMITTER: Perzel Mandell KA
PROVIDER: S-EPMC9133054 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Perzel Mandell Kira A KA Eagles Nicholas J NJ Deep-Soboslay Amy A Tao Ran R Han Shizhong S Wilton Richard R Szalay Alexander S AS Hyde Thomas M TM Kleinman Joel E JE Jaffe Andrew E AE Weinberger Daniel R DR
Molecular psychiatry 20220302 4
Antipsychotic drugs are the current first-line of treatment for schizophrenia and other psychotic conditions. However, their molecular effects on the human brain are poorly studied, due to difficulty of tissue access and confounders associated with disease status. Here we examine differences in gene expression and DNA methylation associated with positive antipsychotic drug toxicology status in the human caudate nucleus. We find no genome-wide significant differences in DNA methylation, but abund ...[more]