Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus.

ABSTRACT: Antipsychotic drugs are the current first-line of treatment for schizophrenia and other psychotic conditions. However, their molecular effects on the human brain are poorly studied, due to difficulty of tissue access and confounders associated with disease status. Here we examine differences in gene expression and DNA methylation associated with positive antipsychotic drug toxicology status in the human caudate nucleus. We find no genome-wide significant differences in DNA methylation, but abundant differences in gene expression. These gene expression differences are overall quite similar to gene expression differences between schizophrenia cases and controls. Interestingly, gene expression differences based on antipsychotic toxicology are different between brain regions, potentially due t

SUBMITTER: Perzel Mandell KA 

PROVIDER: S-EPMC9133054 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature