Physical activity and progression to type 1 diabetes in children and youth with islet autoimmunity: The diabetes autoimmunity study in the young.

ABSTRACT:

Aims/hypotheses

Physical inactivity may contribute to islet autoimmunity and progression to clinical type 1 diabetes. To test this hypothesis, we evaluated physical activity, assessed by accelerometer, as an independent risk factor for progression to clinical diabetes among genetically at risk for type 1 diabetes children and youth with islet autoimmunity.

Methods

Accelerometer data were obtained for 95 children and youth participating in the diabetes autoimmunity study in the young who had islet autoimmunity. Islet autoimmunity was defined as the presence of islet autoantibodies to insulin, glutamic acid decarboxylase, tyrosine phosphatase-like protein IA-2, or zinc transporter 8.

Results

During prospective follow-up for up to 7 years, 13 of the 95 participants progr

SUBMITTER: Snell-Bergeon J 

PROVIDER: S-EPMC9133062 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature