How social/environmental determinants and inflammation affect salivary telomere length among middle-older adults in the health and retirement study.

ABSTRACT: Social epidemiology posits that chronic stress from social determinants will lead to a prolonged inflammatory response that may induce accelerated aging as measured, for example, through telomere length (TL). In this paper, we hypothesize variables across demographic, health-related, and contextual/environmental domains influence the body's stress response, increase inflammation (as measured through high-sensitivity C-reactive protein (hs-CRP)), and thereby lead to shortening of telomeres. This population-based research uses data from the 2008 Health and Retirement Study on participants ages ≤ 54-95 + years, estimating logistic regression and Cox proportional hazards models of variables (with and without confounders) across the domains on shortened TL. A mediation analysis is also conducte

SUBMITTER: Courtney MG 

PROVIDER: S-EPMC9133070 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature