Molecular origin of somatostatin-positive neuron vulnerability.

ABSTRACT: Reduced somatostatin (SST) and dysfunction of SST-positive (SST⁺) neurons are hallmarks of neurological disorders and associated with mood disturbances, but the molecular origin of SST⁺ neuron vulnerability is unknown. Using chronic psychosocial stress as a paradigm to induce elevated behavioral emotionality in rodents, we report a selective vulnerability of SST⁺ neurons through exacerbated unfolded protein response (UPR) of the endoplasmic reticulum (ER), or ER stress, in the prefrontal cortex. We next show that genetically suppressing ER stress in SST⁺ neurons, but not in pyramidal neurons, normalized behavioral emotionality induced by psychosocial stress. In search for intrinsic factors mediating SST⁺ neuron vulnerability, we found

SUBMITTER: Tomoda T 

PROVIDER: S-EPMC9133093 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature