Association of B7-H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer.

ABSTRACT:

Background

B7 homolog 3 (B7-H3) is an immunomodulatory molecule that is highly expressed in prostate cancer (PCa) and belongs to the B7 superfamily, which includes PD-L1. Immunotherapies (antibodies, antibody-drug conjugates, and chimeric antigen receptor T cells) targeting B7-H3 are currently in clinical trials; therefore, elucidating the molecular and immune microenvironment correlates of B7-H3 expression may help to guide trial design and interpretation. The authors tested the interconnected hypotheses that B7-H3 expression is associated with genetic racial ancestry, immune cell composition, and androgen receptor signaling in PCa.

Methods

An automated, clinical-grade immunohistochemistry assay was developed by to digitally quantify B7-H3 protein expression across 2 racial

SUBMITTER: Mendes AA 

PROVIDER: S-EPMC9133095 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature