Distinct inhibitory pathways control velocity and directional tuning in the mouse retina.

ABSTRACT: The sensory periphery is responsible for detecting ethologically relevant features of the external world, using compact, predominantly feedforward circuits. Visual motion is a particularly prevalent sensory feature, the presence of which can be a signal to enact diverse behaviors ranging from gaze stabilization reflexes to predator avoidance or prey capture. To understand how the retina constructs the distinct neural representations required for these behaviors, we investigated two circuits responsible for encoding different aspects of image motion: ON and ON-OFF direction-selective ganglion cells (DSGCs). Using a combination of two-photon targeted whole-cell electrophysiology, pharmacology, and conditional knockout mice, we show that distinct inhibitory pathways independently control tuni

SUBMITTER: Summers MT 

PROVIDER: S-EPMC9133153 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature