Prospective association of psychological pain and hopelessness with suicidal thoughts.

ABSTRACT:

Background

Early markers preceding suicide ideation (SI) may provide valuable information for both assessment and treatment. The glutamatergic modulator ketamine has rapid, transient effects on SI, creating an opportunity to observe potential antecedents of the re-emergence of SI. This analysis evaluated whether the interaction between two suicide risk factors-psychological pain and hopelessness-were prospectively associated with SI post-ketamine administration.

Methods

Data were drawn from three ketamine clinical trials of participants with treatment-resistant major depressive disorder or bipolar disorder (n = 108) with short- and/or long-term follow-up (three or 11 days). A random intercept cross-lagged panel model evaluated the longitudinal relationship between the correl

SUBMITTER: Ballard ED 

PROVIDER: S-EPMC9133160 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature