The EVO study protocol for a randomized controlled evaluation trial of an optimized weight management intervention.

ABSTRACT:

Background

Obesity is a substantial public health concern; however, gold-standard behavioral treatments for obesity are costly and burdensome. Existing adaptations to the efficacious Diabetes Prevention Program (DPP) demonstrate mixed results. Our prior research applying the Multiphase Optimization Strategy (MOST) to DPP identifies a more parsimonious, less costly intervention (EVO) resulting in significant weight loss.

Objective

The aim of the remotely conducted EVO trial is to test the non-inferiority of EVO against DPP. We will conduct economic evaluations alongside the trial to estimate delivery and patient costs, cost-effectiveness, and lifetime healthcare costs of EVO as compared to DPP. Exploratory analyses will examine maintenance, moderators, and mediators of the tr

SUBMITTER: Pfammatter AF 

PROVIDER: S-EPMC9133162 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature