Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity.

ABSTRACT: Nutrient availability varies seasonally and spatially in the wild. While many animals, such as hibernating animals or migrating birds, evolved strategies to overcome periods of nutrient scarcity,^1,2 the cellular mechanisms of these strategies are poorly understood. Cave environments represent an example of nutrient-deprived environments, since the lack of sunlight and therefore primary energy production drastically diminishes the nutrient availability.³ Here, we used Astyanax mexicanus, which includes river-dwelling surface fish and cave-adapted cavefish populations, to study the genetic adaptation to nutrient limitations.^4-9 We show that cavefish populations store large amounts of fat in different body regions when fed ad libitum in t

SUBMITTER: Xiong S 

PROVIDER: S-EPMC9133166 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature