Dataset Information

Relationships between serum iron and liver diseases in nutrition intervention trials: A nested case-control study.

ABSTRACT:

Background

Serum iron is associated with the risk of several diseases. However, limited prospective studies have been performed between serum iron and the subsequent risk of chronic liver disease (CLD) and primary liver cancer (PLC) incidence.

Methods

We performed a nested case-control study using data from the Linxian Nutrition Intervention Trials among participants who developed PLC incidence or died from CLD over 22-years of follow-up. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the risk of PLC incidence or CLD death in different quintile of baseline serum iron using logistic regression.

Results

Individuals with serum iron in the highest quintile, compared to those in the second quintile (the reference), had an increased risk of CLD mortality (OR=2.02, 95% CI=1.27-3.27, P_trend=0.011). The association was stronger among HCV-positive participants (P_interaction=0.005). For PLC incidence, the risk estimates were above one, but not statistically significant (all P > 0.05).

Conclusions

A significant positive association was found between serum iron and the risk of CLD-related mortality, especially in HCV-positive subjects. Our results suggest that serum iron plays a risk role in CLD death but not in PLC incidence.

SUBMITTER: Liu Y

PROVIDER: S-EPMC9133189 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Relationships between serum iron and liver diseases in nutrition intervention trials: A nested case-control study.

Liu Yiwei Y Yin Jian J Dawsey Sanford M SM Liu Bin B Freedman Neal D ND Cui Jianfeng J Taylor Philip R PR Yin Liangyu L Abnet Christian C CC Fan Jinhu J Chen Wen W Zhong Li L Qiao Youlin Y

Cancer epidemiology 20220411

<h4>Background</h4>Serum iron is associated with the risk of several diseases. However, limited prospective studies have been performed between serum iron and the subsequent risk of chronic liver disease (CLD) and primary liver cancer (PLC) incidence.<h4>Methods</h4>We performed a nested case-control study using data from the Linxian Nutrition Intervention Trials among participants who developed PLC incidence or died from CLD over 22-years of follow-up. We calculated the odds ratios (ORs) and 95 ...[more]

PMID: 35421712

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Dataset Information

Relationships between serum iron and liver diseases in nutrition intervention trials: A nested case-control study.

Background

Methods

Results

Conclusions

Publications

Relationships between serum iron and liver diseases in nutrition intervention trials: A nested case-control study.

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