Germline BRCA variants, lifestyle and ovarian cancer survival.

ABSTRACT:

Objective

Women with ovarian cancer who have a pathogenic germline variant in BRCA1 or BRCA2 (BRCA) have been shown to have better 5-year survival after diagnosis than women who are BRCA-wildtype (non-carriers). Modifiable lifestyle factors, including smoking, physical activity and body mass index (BMI) have previously been associated with ovarian cancer survival; however, it is unknown whether these associations differ by germline BRCA status.

Methods

We investigated measures of lifestyle prior to diagnosis in two cohorts of Australian women with invasive epithelial ovarian cancer, using Cox proportional hazards regression to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

In the combined studies (n = 1923), there was little associa

SUBMITTER: Gersekowski K 

PROVIDER: S-EPMC9133192 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature