Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis.

ABSTRACT:

Background

Ketorolac is an opioid sparing agent commonly used in children. However, ketorolac may be avoided in children with peritonitis owing to a possible increased risk of bleeding.

Methods

A retrospective cohort study of healthy children 2-18 years who underwent appendectomy for perforated appendicitis was performed using the Pediatric Health Information System (2009-2019). Multivariable logistic regression was used to evaluate the association between perioperative ketorolac use and postoperative blood transfusions within 30 days of surgery, adjusting for patient and hospital level factors. An interaction between ketorolac and ibuprofen was evaluated to identify synergistic effects.

Results

Overall, 55,603 children with perforated appendicitis underwent appendect

SUBMITTER: Kingston P 

PROVIDER: S-EPMC9133265 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature