TET1 Isoforms Have Distinct Expression Pattern, Localization and Regulation in Breast Cancer.

ABSTRACT: TET1 regulates gene expression by demethylating their regulatory sequences through the conversion of 5-methylcytosine to 5-hyroxymethylcytosine. TET1 plays important roles in tissue homeostasis. In breast cancer, TET1 was shown to play controversial roles. Moreover, TET1 has at least two isoforms (long and short) that have distinct expression pattern and apparently different functions in tissue development and disease including breast cancer. We hypothesized that TET1 isoforms have different expression patterns, localization and regulation in different types of breast cancer. To prove our hypothesis, we studied the expression of TET1 isoforms in basal and luminal breast cancer cell lines, as well as in basal and luminal breast cancer animal models. We also studied the effect of different h

SUBMITTER: Alzahayqa M 

PROVIDER: S-EPMC9133332 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature