The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses.

ABSTRACT: Recent genome-wide association studies (GWASs) of COVID-19 patients of European ancestry have identified genetic loci significantly associated with disease severity. Here, we employed the detailed clinical, immunological and multi-omics dataset of the Human Functional Genomics Project (HFGP) to explore the physiological significance of the host genetic variants that influence susceptibility to severe COVID-19. A genomics investigation intersected with functional characterization of individuals with high genetic risk for severe COVID-19 susceptibility identified several major patterns: i. a large impact of genetically determined innate immune responses in COVID-19, with ii. increased susceptibility for severe disease in individuals with defective cytokine production; iii. genetic susceptibi

SUBMITTER: Kuijpers Y 

PROVIDER: S-EPMC9133558 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature