Ontology highlight
ABSTRACT:
SUBMITTER: Chapple AG
PROVIDER: S-EPMC9133590 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Chapple Andrew G AG Thall Peter F PF
Contemporary clinical trials 20200819
A semi-parametric stochastic ordering model (SPSO) is introduced to characterize functional relationships between dose level and the probabilities of binary Efficacy and Toxicity events. This model is used to implement a Bayesian adaptive phase I-II clinical trial using one of two different optimality criteria, either dose desirability defined as a function of the marginal Efficacy and Toxicity probabilities, or mean utility based on numerical scores of the four possible (Efficacy, Toxicity) eve ...[more]