Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer Development.

ABSTRACT: Ubiquitination and ubiquitin-like post-translational modifications control the activity and stability of different tumor suppressors and oncoproteins. Hence, regulation of this enzymatic cascade offers an appealing scenario for novel antineoplastic targets discovery. Among the different families of enzymes that participate in the conjugation of Ubiquitin, deubiquitinating enzymes (DUBs), responsible for removing ubiquitin or ubiquitin-like peptides from substrate proteins, have attracted increasing attention. In this regard, increasing evidence is accumulating suggesting that the modulation of the catalytic activity of DUBs represents an attractive point of therapeutic intervention in cancer treatment. In particular, different lines of research indicate that USP19, a member of the DUBs, pl

SUBMITTER: Rossi FA 

PROVIDER: S-EPMC9133600 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature